A β-arrestin-biased agonist of 5-HT2A
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IHCH-7079

Item No. 41988

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,6bR,7,8,9,10,10aS-octahydro-8-[2-(2-methoxyphenyl)ethyl]-3-methyl-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
CAS Number
2957888-63-8
Molecular Formula
C23H29N3O
Formula Weight
363.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
SMILES
CN1C2=C3N(CC1)[C@](CCN4CCC(C=CC=C5)=C5OC)([H])[C@](C4)([H])C3=CC=C2
InChi Code
InChI=1S/C23H29N3O/c1-24-14-15-26-20-11-13-25(12-10-17-6-3-4-9-22(17)27-2)16-19(20)18-7-5-8-21(24)23(18)26/h3-9,19-20H,10-16H2,1-2H3/t19-,20-/m0/s1
InChi Key
FCGZRBNMPIAEDK-PMACEKPBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $94

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    5 mg

    $422

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    10 mg

    $748

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    Product Description

    IHCH-7079 is a β-arrestin-biased agonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 16.98 nM).1 It reduces the time spent immobile in the tail suspension and forced swim tests in mice in a model of acute restraint stress-induced depression when administered at a dose of 10 mg/kg, and this effect can be blocked by the 5-HT2A receptor antagonist MDL100907 (volinanserin; Item No. 15936). IHCH-7079 (2 and 10 mg/kg) does not induce the head-twitch response in mice, indicating a lack of hallucinogenic potential.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, D., Yu, J., Wang, H., et al. Structure-based discovery of nonhallucinogenic psychedelic analogs. Science 375(6579), 403-411 (2022).