An ionizable cationic lipid
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C14-490

Item No. 42004

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-[[3-[4-[2-[[3-[bis(2-hydroxytetradecyl)amino]-2-ethoxypropyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis-2-tetradecanol
CAS Number
2639634-82-3
Synonyms
  • B-3
Molecular Formula
C86H177N5O7
Formula Weight
1393.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
OC(CCCCCCCCCCCC)CN(CC(CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)OCC)CCN1CCN(CC(CN(CC(O)CCCCCCCCCCCC)CC(CCCCCCCCCCCC)O)OCC)CC1
InChi Code
InChI=1S/C86H177N5O7/c1-8-15-20-25-30-35-40-45-50-55-60-80(92)71-89(77-86(98-14-7)79-91(74-83(95)63-58-53-48-43-38-33-28-23-18-11-4)75-84(96)64-59-54-49-44-39-34-29-24-19-12-5)70-67-87-65-68-88(69-66-87)76-85(97-13-6)78-90(72-81(93)61-56-51-46-41-36-31-26-21-16-9-2)73-82(94)62-57-52-47-42-37-32-27-22-17-10-3/h80-86,92-96H,8-79H2,1-7H3
InChi Key
VVPCTPAAYAVHBO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    C14-490 is an ionizable cationic lipid (pKa = 5.94).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2 C14-490-containing LNPs accumulate primarily in the fetal mouse liver and, to a lesser extent, in the lungs, intestine, and brain after vitelline vein injection on gestational day 16 (E16).1 CD45-functionalized LNPs containing C14-490 and encapsulating mRNA encoding GFP transfect Jurkat cells, which constitutively express the CD45 receptor (CD45R).2 C14-490-containing CD45-functionalized LNPs encapsulating Cre mRNA mediate genome modulation in bone marrow hematopoietic stem cells (HSCs) for at least four months after in utero injection in R26mT/mG mice at E13.5.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riley, R.S., Kashyap, M.V., Billingsley, M.M., et al. Ionizable lipid nanoparticles for in utero mRNA delivery. Sci. Adv. 7(3), eaba1028 (2021).

    2. Palanki, R., Riley, J.S., Bose, S.K., et al. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 121(32), e2400783121 (2024).