A GPX4 inhibitor and ferroptosis inducer
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GPX4 Inhibitor 17

Item No. 42006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Glutathione Peroxidase 4-IN-17
  • Glutathione Peroxidase 4 Inhibitor 17
  • GPX4-IN-17
Molecular Formula
C30H27ClFeN2O3
Formula Weight
554.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
[][Fe][].O=C(C#C)N(C1=CC=C(OC)C(Cl)=C1)C(c2cccc2)C(NCCC3=CC=CC=C3)=O.c4cccc4
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $318

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    10 mg

    $599

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    Cayman Chemical
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    Product Description

    GPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.1 It inhibits GPX4 activity by 49.16% when used at a concentration of 1 µM. GPX4 inhibitor 17 (0.5 µM) increases the production of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) in OS-RC-2 clear cell renal cell carcinoma cells. It induces ferroptosis in HT-1080 cells (IC50s = 0.007 and 1.486 µM, in the absence and presence of ferrostatin-1, respectively). GPX4 inhibitor 17 (20 mg/kg) reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W., Yu, J., Wang, J., et al. How does ferrocene correlate with ferroptosis? Multiple approaches to explore ferrocene-appended GPX4 inhibitors as anticancer agents. Chem. Sci. 15(27), 10477-10490 (2024).