A chemoselective probe for protein sulfenylation
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WYneN

Item No. 42010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-phosphonium, monobromide
CAS Number
3052492-38-0
Synonyms
  • Wittig-alkyne N
Molecular Formula
C23H21NOP • Br
Formula Weight
438.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NCC#C)C[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]
InChi Code
InChI=1S/C23H20NOP.BrH/c1-2-18-24-23(25)19-26(20-12-6-3-7-13-20,21-14-8-4-9-15-21)22-16-10-5-11-17-22;/h1,3-17H,18-19H2;1H
InChi Key
YPEUZRGPBBUWJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $109

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    25 mg

    $231

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    50 mg

    $409

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    Product Description

    WYneN is a chemoselective probe for the detection of sulfenylated proteins in live cells.1 It is selective for sulfenylated proteins over 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) and 4,4′-dipyridyl disulfide (4-DPS). WYneN binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shi, Y., Fu, L., Yang, J., et al. Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting. Nat. Chem. 13(11), 1140-1150 (2021).