An ionizable cationic lipid
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A28-C6B2

Item No. 42017

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-butyloctyl) 6,6'-((5-hydroxypentyl)azanediyl)dihexanoate
Molecular Formula
C41H81NO5
Formula Weight
668.1
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCC(COC(CCCCCN(CCCCCC(OCC(CCCC)CCCCCC)=O)CCCCCO)=O)CCCC
InChi Code
InChI=1S/C41H81NO5/c1-5-9-13-18-28-38(26-11-7-3)36-46-40(44)30-20-15-22-32-42(34-24-17-25-35-43)33-23-16-21-31-41(45)47-37-39(27-12-8-4)29-19-14-10-6-2/h38-39,43H,5-37H2,1-4H3
InChi Key
LRSNKXRFKNSFSY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $105

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    5 mg

    $497

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    10 mg

    $941

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    Cayman Chemical
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    Product Description

    A28-C6B2 is an ionizable cationic lipid (pKa = 6.43) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing A28-C6B2 accumulate primarily in the spleen in mice after intravenous administration and target F4/80+ macrophages, Cd11c+ dendritic cells, and to a lesser extent, T cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, Y., Zeng, L., Tang, Y., et al. Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles. J. Mater. Chem. B. 12(33), 8062-8066 (2024).