An antidepressant
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Metapramine

Item No. 42033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine
CAS Number
21730-16-5
Synonyms
  • RP 19560
Molecular Formula
C16H18N2
Formula Weight
238.3
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CN1C2=C(C=CC=C2)C(NC)CC3=C1C=CC=C3
InChi Code
InChI=1S/C16H18N2/c1-17-14-11-12-7-3-5-9-15(12)18(2)16-10-6-4-8-13(14)16/h3-10,14,17H,11H2,1-2H3
InChi Key
YXVZOBVWVRFPTE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $125

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    10 mg

    $220

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    25 mg

    $482

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    Product Description

    Metapramine is an antidepressant.1 It decreases action potential amplitude and maximal signal velocity and increases conduction time in isolated dog Purkinje fibers when used at a concentration of 10 µM. Metapramine (10 mg/kg) reduces ethanol consumption in ethanol-preferring rats.2 It inhibits reperfusion-induced increases in ventricular arrhythmias in a rat model of myocardial ischemia-reperfusion injury induced by ligation of the left anterior descending (LAD) artery when used at a concentration of 175 µM.3 Metapramine (10 mg/kg) increases the latency to tail withdrawal in the tail-flick test and inhibits phenylbenzoquinone-induced writhing in mice when administered at a dose of 10 mg/kg.4 Formulations containing metapramine have been used in the treatment of depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bril, A., Rochette, L., Bertrand, J.P., et al. Electrophysiological effects of some antidepressant drugs on canine cardiac Purkinje fibres. Cardiovasc. Res. 21(11), 783-789 (1987).

    2. Daoust, M., Saligaut, C., Chadelaud, M., et al. Attenuation by antidepressant drugs of alcohol intake in rats. Alcohol 1(5), 379-383 (1984).

    3. Bril, A., and Rochette, L. Comparison of the effect of antidepressant drugs on arrhythmias in the isolated rat heart subjected to myocardial ischaemia and reperfusion. Pharmacol. Toxicol. 60(4), 249-254 (1987).

    4. Michael-Titus, A., and Costentin, J. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain 31(3), 391-400 (1987).