An SST2 agonist
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Paltusotine

Item No. 42041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-benzonitrile
CAS Number
2172870-89-0
Synonyms
  • CRN00808
Molecular Formula
C27H22F2N4O
Formula Weight
456.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
N#CC1=C(O)C(C2=CC3=C(N4CCC(CC4)N)C(C5=CC(F)=CC(F)=C5)=CN=C3C=C2)=CC=C1
InChi Code
InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
InChi Key
GHILNKWBALQPDP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $303

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    10 mg

    $484

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    25 mg

    $1,060

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    50 mg

    $1,513

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    Product Description

    Paltusotine is a nonpeptide somatostatin receptor 2 (SST2) agonist.1 It selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively). In vivo, paltusotine (3, 10, and 30 mg/kg) reduces growth hormone release stimulated by growth hormone-releasing hormone (GHRH) in rats. It also reduces plasma levels of insulin-like growth factor 1 (IGF-1) in beagle dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, J., Wang, S., Markison, S., et al. Discovery of paltusotine (CRN00808), a potent, selective, and orally bioavailable non-peptide SST2 agonist. ACS Med. Chem. Lett. 14(1), 66-74 (2022).