A PDE10A inhibitor
Related Products
Isomer(s)
18266PF-2545920
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PF-02545920

Item No. 42047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[1-methyl-3-(4-pyridinyl)-1H-pyrazol-4-yl]phenoxy]methyl]-quinoline
CAS Number
898563-49-0
Molecular Formula
C25H20N4O
Formula Weight
392.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mL
SMILES
CN1N=C(C2=CC=NC=C2)C(C3=CC=C(OCC4=NC5=C(C=CC=C5)C=C4)C=C3)=C1
InChi Code
InChI=1S/C25H20N4O/c1-29-16-23(25(28-29)20-12-14-26-15-13-20)18-7-10-22(11-8-18)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
InChi Key
AESZYYCTKODVMP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $204

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    10 mg

    $387

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    25 mg

    $858

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    Product Description

    PF-02545920 is an inhibitor of phosphodiesterase 10A (PDE10A; IC50 = 29 nM).1 It inhibits PCP-induced hyperactivity in mice when administered at doses of 30 or 100 mg/kg. PF-02545920 (0.1 or 0.3 mg/kg) reverses PCP-induced deficits in the novel object recognition test in neonatal mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamaguchi, W., Masuda, N., Samizu, K., et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem. Pharm. Bull. (Tokyo) 62(12), 1200-1213 (2014).