An inhibitor of the protein-protein interaction between Trx and caspase-3
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Apoptosis

KEA1-97

Item No. 42049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-dichloro-N-(4′-fluoro[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine
CAS Number
2138882-71-8
Molecular Formula
C15H9Cl2FN4
Formula Weight
335.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=NC(Cl)=NC(NC2=CC=C(C3=CC=C(F)C=C3)C=C2)=N1
InChi Code
InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)
InChi Key
DUROVTLUQOYUPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $50

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    10 mg

    $90

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    25 mg

    $186

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    50 mg

    $297

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    Cayman Chemical
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    Product Description

    KEA1-97 is a dichlorotriazine (DCT) inhibitor of the protein-protein interaction between thioredoxin (Trx) and caspase-3.1 It binds to lysine 72 (K72) of Trx and inhibits DCT-alkyne labeling of recombinant Trx at K72 (IC50 = 10 µM). KEA1-97 (100 µM) inhibits the interaction between Trx and caspase-3 in a cell-free assay. It reduces survival and proliferation of and induces apoptosis in Trx-overexpressing 231MFP breast cancer cells. In vivo, KEA1-97 (5 mg/kg) reduces tumor volume in a 231MFP mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anderson, K.E., To, M., Olzmann, J.A., et al. Chemoproteomics-enabled covalent ligand screening reveals a thioredoxin-caspase 3 interaction disruptor that impairs breast cancer pathogenicity. ACS Chem. Biol. 12(10), 2522-2528 (2017).