A cereblon ligand 1-containing degrader of IKZF1 and IKZF3
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CFT-7455

Item No. 42053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione
CAS Number
2504235-67-8
Synonyms
  • Cemsidomide
Molecular Formula
C28H27N3O4
Formula Weight
469.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly Soluble: 1-10 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C1N([C@@H]2C(NC(CC2)=O)=O)C3=CC=C(C4=CC=CC1=C43)CC5=CC=C(C=C5)CN6CCOCC6
InChi Code
InChI=1S/C28H27N3O4/c32-25-11-10-24(27(33)29-25)31-23-9-8-20(21-2-1-3-22(26(21)23)28(31)34)16-18-4-6-19(7-5-18)17-30-12-14-35-15-13-30/h1-9,24H,10-17H2,(H,29,32,33)/t24-/m0/s1
InChi Key
MUKCJOOKCZSQNW-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $79

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    5 mg

    $371

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    10 mg

    $703

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    25 mg

    $1,368

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    Cayman Chemical
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    Product Description

    CFT-7455 is a cereblon ligand 1-containing degrader of Ikaros family zinc finger protein 1 (IKZF1) and IKZF3.1 It reduces levels of IKZF1 and IKZF3 in NCI H929 B cell myeloma cells when used at a concentration of 0.1 nM. CFT-7455 decreases the growth of NCI H929 cells (GI50 = 0.0743 nM). It reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model when administered at doses of 30 or 100 µg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Proia, D., Henderson, J.A., He, M., et al. Advantageous therapies for disorders mediated by karos or aiolos. (2022).