An LMW-PTP inhibitor
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SPAA-52 (ammonium salt)

Item No. 42076

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(3,5-dibromo-4-methylphenyl)amino]carbonyl]-sulfamic acid, monoammonium salt
Molecular Formula
C8H7Br2N2O4S • NH4
Formula Weight
405.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
[O-]S(=O)(NC(NC(C=C1Br)=CC(Br)=C1C)=O)=O.[NH4+]
InChi Code
InChI=1S/C8H8Br2N2O4S.H3N/c1-4-6(9)2-5(3-7(4)10)11-8(13)12-17(14,15)16;/h2-3H,1H3,(H2,11,12,13)(H,14,15,16);1H3
InChi Key
RMSNSCWKISLJSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $216

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    10 mg

    $378

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    Product Description

    SPAA-52 is an inhibitor of low molecular weight protein tyrosine phosphatase (LMW-PTP; Ki = 1.2 nM).1 It is greater than 8,000-fold selective for LMW-PTP over 24 phosphatases at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, R., Wang, J., Yu, Z.H., et al. Structure-based design of active-site-directed, highly potent, selective, and orally bioavailable low-molecular-weight protein tyrosine phosphatase inhibitors. J. Med. Chem. 65(20), 13892-13909 (2022).