An ALDH1A3 inhibitor
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MCI-INI-3

Item No. 42077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylic acid, methyl ester
CAS Number
1011366-31-6
Molecular Formula
C21H15N3O4
Formula Weight
373.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC(C2=CC3=C(OCO3)C=C2)=NC4=CC(C5=CC=CC=C5)=NN41)OC
InChi Code
InChI=1S/C21H15N3O4/c1-26-21(25)17-10-15(14-7-8-18-19(9-14)28-12-27-18)22-20-11-16(23-24(17)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3
InChi Key
DCSWTUKGGUNNLU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $517

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    10 mg

    $981

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    Product Description

    MCI-INI-3 is an inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3; Ki = 0.55 µM).1 It is selective for ALDH1A3 over ALDH1A1 (Ki = 78.2 µM). MCI-INI-3 (15 µM) inhibits the conversion of retinol to retinaldehyde in U87MG glioblastoma cells. It reduces the viability of GSC-83 and GSC-326 glioblastoma cells when used at a concentration of 15 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J., Garavaglia, S., Ye, Z., et al. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Commun. Biol. 4(1), 1420 (2021).