A peptide substrate of IRAK4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Peptides

Application

Enzyme Activity

IRAK1 (360-380) (trifluoroacetate salt)

Item No. 42080

Product Insert (PDF)
Technical Information
Formal Name
(2S,5S,8S,11S,14S,17S,20S,23S)-20-(3-amino-3-oxopropyl)-24-((S)-2-(((2S,5S,11S,14S,17S,20S,23S,26S,29S,32S,35S)-39-amino-32-(4-aminobutyl)-14,23-dibenzyl-17,26-bis(3-((diaminomethylene)amino)propyl)-35-formyl-1-hydroxy-5,20-bis(hydroxymethyl)-11,29-dimethyl-3,6,9,12,15,16,21,24,25,30,33-undecaoxo-4,7,10,13,18,19,22,27,28,31,34-undecaazanonatriacontan-2-yl)carbamoyl)pyrrolidin-1-yl)-2-(3-((diaminomethylene)amino)propyl)-14,17,23-tris(hydroxymethyl)-8-isopropyl-5-methyl-11-(2-(methylthio)ethyl)-6,9,12,15,18,21,24-heptaoxo-3,4,7,10,13,16,19,22-octaazatetracosanoic acid, trifluoroacetate salt
Synonyms
  • IL-1 Receptor-associated Kinase 1
  • Interleukin-1 Receptor-associated Kinase 1
  • IRAK4 Peptide Substrate
Molecular Formula
C97H161N33O29S • XCF3COOH
Formula Weight
2285.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KKARFSRFAGSSPSQSSMVAR-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CO[H])C(N[C@@H](CO[H])C(N1CCC[C@H]1C(N[C@@H](CO[H])C(N[C@@H](CCC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CO[H])C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)C)=O)[C@H](CCCCN[H])N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C97H161N33O29S.C2HF3O2/c1-50(2)74(92(156)114-53(5)77(141)121-62(94(158)159)29-19-38-110-97(106)107)129-83(147)61(33-40-160-6)120-88(152)67(46-133)126-90(154)68(47-134)124-82(146)60(31-32-72(101)137)119-89(153)69(48-135)127-91(155)71-30-20-39-130(71)93(157)70(49-136)128-86(150)65(44-131)115-73(138)43-111-75(139)51(3)112-84(148)63(41-54-21-9-7-10-22-54)122-81(145)59(28-18-37-109-96(104)105)118-87(151)66(45-132)125-85(149)64(42-55-23-11-8-12-24-55)123-80(144)58(27-17-36-108-95(102)103)116-76(140)52(4)113-79(143)57(26-14-16-35-99)117-78(142)56(100)25-13-15-34-98;3-2(4,5)1(6)7/h7-12,21-24,50-53,56-71,74,131-136H,13-20,25-49,98-100H2,1-6H3,(H2,101,137)(H,111,139)(H,112,148)(H,113,143)(H,114,156)(H,115,138)(H,116,140)(H,117,142)(H,118,151)(H,119,153)(H,120,152)(H,121,141)(H,122,145)(H,123,144)(H,124,146)(H,125,149)(H,126,154)(H,127,155)(H,128,150)(H,129,147)(H,158,159)(H4,102,103,108)(H4,104,105,109)(H4,106,107,110);(H,6,7)/t51-,52-,53-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-;/m0./s1
InChi Key
UGNHOQJQXORBPL-VECQAQGTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $65

    Add

    10 mg

    $124

    Add

    25 mg

    $293

    Add

    50 mg

    $520

    Add
    Product Description

    IL-1 receptor-associated kinase 1 (IRAK1) (360-380) is a peptide substrate of IRAK4.1 It has been used in competition assays to identify inhibitors of IRAK4.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Song, K.W., Talamas, F.X., Suttmann, R.T., et al. The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells. Mol. Immunol. 46(7), 1458-1466 (2009).

    2. Kuglstatter, A., Villaseñor, A.G., Shaw, D., et al. Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations. J. Immunol. 178(5), 2641-2645 (2007).