A peptide agonist of melanocortin receptors
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CTX-1211 (trifluoroacetate salt)

Item No. 42081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-arginyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2→8)-disulfide, trifluoroacetate salt
Synonyms
  • Acetyl-Arg-cyclo(Cys-D-Ala-Arg-D-Phe-Arg-Trp-Cys)-NH2
Molecular Formula
C49H73N19O9S2 • XCF3COOH
Formula Weight
1136.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-R-cyclo(CaRfRWC)-NH2
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@@H](CSSC[C@@H](C(N[C@@H]1C)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)[C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)CC3=CNC4=CC=CC=C34.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C49H73N19O9S2.C2HF3O2/c1-26-40(71)63-33(16-9-19-58-48(53)54)42(73)65-35(21-28-11-4-3-5-12-28)44(75)64-34(17-10-20-59-49(55)56)43(74)66-36(22-29-23-60-31-14-7-6-13-30(29)31)45(76)67-37(39(50)70)24-78-79-25-38(46(77)61-26)68-41(72)32(62-27(2)69)15-8-18-57-47(51)52;3-2(4,5)1(6)7/h3-7,11-14,23,26,32-38,60H,8-10,15-22,24-25H2,1-2H3,(H2,50,70)(H,61,77)(H,62,69)(H,63,71)(H,64,75)(H,65,73)(H,66,74)(H,67,76)(H,68,72)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59);(H,6,7)/t26-,32+,33+,34+,35-,36+,37+,38+;/m1./s1
InChi Key
QRLRDGUPSFZYLV-CPUQZFJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $299

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    5 mg

    $598

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    10 mg

    $897

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    25 mg

    $1,869

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    Product Description

    CTX-1211 is a peptide agonist of melanocortin receptors.1 It increases intracellular cAMP levels in cells expressing melanocortin receptor 1 (MC1R), MC3R, or MC4R (EC50s = 6.2, 3.9, and 2.7, nM, respectively). CTX-1211 (1 mg/kg) sensitizes male and female mice to reductions in food intake and body weight induced by liraglutide (Item No. 24727) but with a lower effect on food intake in female mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, S. Peptide Compositions. (2014).

    2. Dahir, N.S., Gui, Y., Wu, Y., et al. Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice. J. Clin. Invest. 134(14), e178250 (2024).