Host: Insect cells • AA: 2-631 • Tag: N-terminal DYKDDDDK • MW: 67 kDa
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HDAC10 (human, recombinant)

Item No. 42085

Product Insert (PDF)
Technical Information
Synonyms
  • Histone Deacetylase 10
Purity
≥62% estimated by SDS-PAGE
Source
Recombinant human N-terminal DYKDDDDK-tagged HDAC10 expressed in insect cells
Amino Acids
2-631
MW
67 kDa
Formulation (Request formulation change)
40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 0.04% Tween-20, 20% glycerol, and 90 µg/ml DYKDDDDK peptide
UniProt Accession №
Q969S8
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $451

    Add
    Cayman Chemical
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    Product Description

    Histone deacetylase 10 (HDAC10) is a zinc-dependent metalloenzyme and class IIb HDAC.1 It is composed of an N-terminal catalytic domain and a C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and shuttles between the cytoplasm and nucleus.2 It acts as a transcriptional corepressor and deacetylates histones and polyamines, such as N8-acetylspermidine.2,3 HDAC10 is involved in DNA damage repair, autophagy, and inflammation.4 Overexpression of HDAC10 promotes proliferation of lung cancer cells in vitro, and knockout of Hdac10 protects mice against allergic airway inflammation.5,6 SNPs in HDAC10 have been found in patients with schizophrenia.7 Cayman’s HDAC10 (human, recombinant) protein has a calculated molecular weight of 67 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, X.J., and Grégoire, S. Class II histone deacetylases: From sequence to function, regulation, and clinical implication. Mol. Cell. Biol. 25(8), 2873-2884 (2005).

    2. Kao, H.-Y., Lee, C.-H., Komarov, A., et al. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. The Journal of Biological Chemisty 277(1), 187-193 (2002).

    3. Hai, Y., Shinsky, S.A., Porter, N.J., et al. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat. Commun. 8:15368, (2017).

    4. Cheng, F., Zheng, B., Wang, J., et al. Histone deacetylase 10, a potential epigenetic target for therapy. Biosci. Rep. 41(6), BSR20210462 (2021).

    5. Yang, Y., Huang, Y., Wang, Z., et al. HDAC10 promotes lung cancer proliferation via AKT phosphorylation. Oncotarget 7(37), 59388-59401 (2016).

    6. Zhong, Y., Huang, T., Huang, J., et al. The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation. Theranostics 13(11), 3568-3581 (2023).

    7. Kebir, O., Chaumette, B., Fatjó-Vilas, M., et al. Family-based association study of common variants, rare mutation study and epistatic interaction detection in HDAC genes in schizophrenia. Schizophr. Res. 160(1-3), 97-103 (2014).