An AQP4 facilitator
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TGN 073

Item No. 42086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(phenylmethoxy)-2-pyridinyl]-benzenesulfonamide
CAS Number
877459-36-4
Molecular Formula
C18H16N2O3S
Formula Weight
340.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mL
SMILES
O=S(NC1=NC=CC=C1OCC2=CC=CC=C2)(C3=CC=CC=C3)=O
InChi Code
InChI=1S/C18H16N2O3S/c21-24(22,16-10-5-2-6-11-16)20-18-17(12-7-13-19-18)23-14-15-8-3-1-4-9-15/h1-13H,14H2,(H,19,20)
InChi Key
JBHHMMLJGNLVNB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $61

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    10 mg

    $116

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    50 mg

    $484

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    100 mg

    $847

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    Product Description

    TGN 073 is a facilitator of aquaporin-4 (AQP4), an astroglial water channel.1,2 It increases glymphatic transport and parenchymal penetration of a gadolinium-based tracer in rats when administered intraperitoneally at a dose of 200 mg/kg.1 TGN 073 (200 mg/kg, i.p.) increases AQP4 polarization and reduces brain retention of exogenous amyloid-ß (1-40) (Aß40) in mice fed a high-fat diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alghanimy, A., Martin, C., Gallagher, L., et al. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS One 18(3), e0282955 (2023).

    2. Peng, W., Yuan, Y., Lei, J., et al. Long-term high-fat diet impairs AQP4-mediated glymphatic clearance of amyloid beta. Mol. Neurobiol. (2024).