A covalent inhibitor of GAPDH
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GAPDH Inhibitor Compound F8

Item No. 42090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole
CAS Number
252212-58-1
Molecular Formula
C20H18N2O5
Formula Weight
366.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
C1(C2=CC(OCC3OC3)=CC=C2)=NN=C(C4=CC=CC(OCC5CO5)=C4)O1
InChi Code
InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2
InChi Key
IQCCNCOQRRJSTE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $174

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    Product Description

    GAPDH inhibitor compound F8 is a covalent inhibitor of GAPDH (IC50 = 39.31 µM).1 It viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, Y., Noda, N., Takaya, J., et al. Discovery of non-cysteine-targeting covalent inhibitors by activity-based proteomic screening with a cysteine-reactive probe. ACS Chem. Biol. 17(2), 340-347 (2022).