A GPR18 agonist
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PSB-KK1445

Item No. 42093

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[(4-fluorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
885896-54-8
Molecular Formula
C24H23FN6O2
Formula Weight
446.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1C2=C(N(C)C(N1C)=O)N=C(N2CC3=CC=C(C=C3)F)NCCC4=CNC5=C4C=CC=C5
InChi Code
InChI=1S/C24H23FN6O2/c1-29-21-20(22(32)30(2)24(29)33)31(14-15-7-9-17(25)10-8-15)23(28-21)26-12-11-16-13-27-19-6-4-3-5-18(16)19/h3-10,13,27H,11-12,14H2,1-2H3,(H,26,28)
InChi Key
JMZXYZSTEKMPDV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $51

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    10 mg

    $96

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    25 mg

    $228

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    50 mg

    $405

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    Product Description

    PSB-KK1445 is an agonist of GPR18.1 It is selective for GPR18 over GPR55 in β-arrestin recruitment assays using CHO-K1 cells expressing the human receptors (EC50s = 0.0454 and >10 µM, respectively) and does not bind to cannabinoid 1 (CB1) or CB2 receptors (Kis = >10 µM for both).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahardhika, A.B., Załuski, M., Schoeder, C.T., et al. Potent, selective agonists for the cannabinoid-like orphan G protein-coupled receptor GPR18: A promising drug target for cancer and immunity. J. Med. Chem. 67(12), 9896-9926 (2024).