A styryl dye and an inhibitor of mechanosensitive ion channels
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FM™1-43

Item No. 42094

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[4-(dibutylamino)phenyl]ethenyl]-1-[3-(triethylammonio)propyl]-pyridinium, dibromide
CAS Number
149838-22-2
Molecular Formula
C30H49N3 • 2Br
Formula Weight
611.5
Emission
535 nm
Excitation
485 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
λmax
516 nm
SMILES
CC[N+](CC)(CC)CCC[N+](C=C1)=CC=C1C=CC2=CC=C(N(CCCC)CCCC)C=C2.[Br-].[Br-]
InChi Code
InChI=1S/C30H49N3.2BrH/c1-6-11-23-32(24-12-7-2)30-18-16-28(17-19-30)14-15-29-20-25-31(26-21-29)22-13-27-33(8-3,9-4)10-5;;/h14-21,25-26H,6-13,22-24,27H2,1-5H3;2*1H/q+2;;/p-2
InChi Key
VZUVCAGXYLMFEC-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    5 mg

    $278

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    10 mg

    $525

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    25 mg

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    Product Description

    FM™1-43 is a cationic styryl pyridinium dye and an inhibitor of mechanosensitive ion channels.1,2 It reversibly binds to, but does not permeate, cell membranes and has been used to monitor synaptogenesis and reinnervation, endocytosis, and vacuole formation in vitro. FM™1-43 (0.6-15 µM) inhibits rapidly and slowly adapting mechanically activated currents in both capsaicin-insensitive and capsaicin-sensitive isolated rat dorsal root ganglion neurons.2 It displays excitation/emission maxima of 485/535 nm, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cochilla, A.J., Angleson, J.K., and Betz, W.J. Monitoring secretory membrane with FM1-43 fluorescence. Annu. Rev. Neurosci. 22, 1-10 (1999).

    2. Drew, L.J., and Wood, J.N. FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli. Mol. Pain 3, 1 (2007).