An HDAC inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Martinostat

Item No. 42100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide
CAS Number
1629052-58-9
Molecular Formula
C22H30N2O2
Formula Weight
354.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
CN(CC(C=C1)=CC=C1/C=C/C(NO)=O)CC2(C[C@@H](C3)C4)C[C@@H]4C[C@@H]3C2
InChi Code
InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+/t18-,19+,20-,22?
InChi Key
WNIDBXBLQFPAJA-FQRVRAMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $109

    Add

    10 mg

    $196

    Add

    25 mg

    $382

    Add

    50 mg

    $600

    Add
    Product Description

    Martinostat is an inhibitor of histone deacetylase 1 (HDAC1), HDAC2, HDAC3, and HDAC6 (IC50s = 0.3, 2, 0.6, and 4.1 nM, respectively).1 It is selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively). Martinostat reduces lysine 9 on histone 3 acetylation (H3K9ac) and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, C., Schroeder, F.A., Wey, H.Y., et al. In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J. Med. Chem. 57(19), 7999-8009 (2014).