A G-quadruplex stabilizer
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BMVC-8C3O

Item No. 42109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-[[9-[2-[2-[2-[2-(1-methylpiperidinio)ethoxy]ethoxy]ethoxy]ethyl]-9H-carbazole-3,6-diyl]di-2,1-ethenediyl]bis[1-methyl-pyridinium], triiodide
CAS Number
1301708-12-2
Molecular Formula
C42H53N4O3 • 3I
Formula Weight
1042.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
C[N+](C=C1)=CC=C1C=CC(C=C2C3=C4C=CC(C=CC5=CC=[N+](C)C=C5)=C3)=CC=C2N4CCOCCOCCOCC[N+]6(CCCCC6)C.[I-].[I-].[I-]
InChi Code
InChI=1S/C42H53N4O3.3HI/c1-43-19-15-35(16-20-43)7-9-37-11-13-41-39(33-37)40-34-38(10-8-36-17-21-44(2)22-18-36)12-14-42(40)45(41)23-27-47-29-31-49-32-30-48-28-26-46(3)24-5-4-6-25-46;;;/h7-22,33-34H,4-6,23-32H2,1-3H3;3*1H/q+3;;;/p-3
InChi Key
DKMJOQQQBQBOMV-UHFFFAOYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $276

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    10 mg

    $423

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    25 mg

    $569

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    Cayman Chemical
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    Product Description

    BMVC-8C3O is a G-quadruplex (G4) stabilizer.1 It increases the melting temperature of human telomeres by 45°C in a potassium solution. BMVC-8C3O binds to G4 structures at the EGFR promoter (Kd = 74.3 and 246.4 nM for QFS1 and QFS2, respectively), reduces EGFR protein levels, and inhibits the growth of several non-small cell lung cancer (NSCLC) cell lines, including those resistant to osimertinib (AZD 9291; Item No. 16237), in a concentration-dependent manner.2 In vivo, BMVC-8C3O (3 mg/kg) reduces tumor volume and weight in an H1975 NSCLC mouse xenograft model. It is also active against several strains of M. tuberculosis (MICs = 5.492-25 µg/ml) and inhibits M. tuberculosis polyketide synthase 13 (Pks13; IC50 = 6.94 µM), an enzyme involved in mycolic acid biosynthesis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Z.-F., and Chang, T.-C. Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol. Nucleic Acids Res. 40(17), 8711-8720 (2012).

    2. Lu, K., Wang, H.-C., Tu, Y.-C., et al. EGFR suppression contributes to growth inhibitory activity of G-quadruplex ligands in non-small cell lung cancers. Biochem. Pharmacol. 216, 115788 (2023).

    3. Liu, T., Meng, J., Wang, B., et al. Identification of BMVC-8C3O as a novel Pks13 inhibitor with anti-tuberculosis activity. Tuberculosis (Edinb) 150, 102579 (2025).