Dendrophenol

Dendrophenol is a polyphenol that has been found in D. nobile and has diverse biological activities.^1,2,3 It decreases viability of, and induces cell cycle arrest at the S phase in, HCT116 colorectal cancer cells when used at a concentration of 10 µM.¹ Dendrophenol (3 or 10 µM) inhibits the migration of MDA-MB-231 breast cancer cells.² It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, hypoxia-inducible factor-1α (HIF-1α), and NF-κB levels and NF-κB nuclear translocation in RAW 264.7 macrophages when used at a concentration of 100 µM.³ Dendrophenol (50 or 100 mg/kg per day) reduces tumor size without affecting body weight in an HCT116 mouse xenograft model.¹ It decreases total lung weight in an MDA-MB-231 mouse xenograft model when administered at a dose of 100 mg/kg per day.²

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1. Chen, T.-H., Pan, S.-L., Guh, J.-H., et al. Moscatilin induces apoptosis in human colorectal cancer cells: A crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin. Cancer Res. 14(13), 4250-4258 (2008).

2. Pai, H.-C., Chang, L.-H., Peng, C.-Y., et al. Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway. J. Mol. Med. (Berl) 91(3), 347-356 (2013).

3. Liu, Y.-N., Pan, S.-L., Peng, C.-Y., et al. Moscatilin repressed lipopolysaccharide-induced HIF-1α accumulation and NF-κB activation in murine RAW264.7 cells. Shock 33(1), 70-75 (2010).