A prodrug form of ravuconazole
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Fosravuconazole (L-lysine ethanolate)

Item No. 42133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-Lysine, compd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1)
CAS Number
914361-45-8
Synonyms
  • BMS 379224
  • E1224
  • F-RVCZ
Molecular Formula
C23H20F2N5O5PS • C6H14N2O2 • C2H6O
Formula Weight
739.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
CCO.NCCCC[C@H](N)C(O)=O.N#CC(C=C1)=CC=C1C2=CSC([C@H](C)[C@](OCOP(O)(O)=O)(CN3N=CN=C3)C4=C(F)C=C(F)C=C4)=N2
InChi Code
InChI=1S/C23H20F2N5O5PS.C6H14N2O2.C2H6O/c1-15(22-29-21(10-37-22)17-4-2-16(9-26)3-5-17)23(11-30-13-27-12-28-30,34-14-35-36(31,32)33)19-7-6-18(24)8-20(19)25;7-4-2-1-3-5(8)6(9)10;1-2-3/h2-8,10,12-13,15H,11,14H2,1H3,(H2,31,32,33);5H,1-4,7-8H2,(H,9,10);3H,2H2,1H3/t15-,23+;5-;/m00./s1
InChi Key
VOWYGLHOVNSCSA-NRVKWRQJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Fosravuconazole is a prodrug form of the triazole antifungal agent ravuconazole (Item No. 18750).1 It increases survival in a mouse model of systemic C. albicans infection. Formulations containing fosravuconazole have been used in the treatment of onychomycosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ueda, Y., Matiskella, J.D., Golik, J., et al. Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties. Bioorg. Med. Chem. Lett. 13(21), 3669-3672 (2003).