An α4β2 subunit-containing nAChR agonist
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Rivanicline (hydrochloride)

Item No. 42184

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-N-methyl-4-(pyridin-3-yl)but-3-en-1- amine, hydrochloride
Synonyms
  • RJR-2403
  • trans-Metanicotine
Molecular Formula
C10H14N2 • XHCl
Formula Weight
162.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
CNCC/C=C/C1=CN=CC=C1.Cl
InChi Code
InChI=1S/C10H14N2.ClH/c1-11-7-3-2-5-10-6-4-8-12-9-10;/h2,4-6,8-9,11H,3,7H2,1H3;1H/b5-2+;
InChi Key
HGCYAFBPAWHPTH-DPZBITMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $87

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    10 mg

    $136

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    Product Description

    Rivanicline is an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs).1 It selectively induces rubidium ion efflux in M10 cells expressing α4β2 subunit-containing nAChRs (EC50 = 0.73 µM for the chicken channels) over M10 cells expressing α3β4- or α1β1γδ subunit-containing nAChRs (EC50s = >1,000 nM for both for the chicken channels) and a panel of 34 receptors, ion channels, and kinases at 10 µM. It induces contractions in isolated guinea pig ileum (EC30 = 15 µM). Rivanicline (0.6 µmol/kg) prevents scopolamine-induced memory deficits in the passive avoidance test in mice.2 It decreases the number of errors in the radial arm maze in a rat model of ibotenic acid-induced memory impairment when administered at doses of 0.3, 0.6 or 1.2 µmol/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bencherif, M., Lovette, M.E., Fowler, K.W., et al. RJR-2403: A nicotinic agonist with CNS selectivity I. In vitro characterization. J. Pharmacol. Exp. Ther. 279(3), 1413-1421 (1996).

    2. Lippiello, P.M., Bencherif, M., Gray, J.A., et al. RJR-2403: A nicotinic agonist with CNS selectivity II. In vivo characterization. J. Pharmacol. Exp. Ther. 279(3), 1422-1429 (1996).