An AMPA receptor positive allosteric modulator
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TAK-653

Item No. 42187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[4-(cyclohexyloxy)phenyl]-3,4- dihydro-7-methyl-pyrazino[2,1-c][1,2,4]thiadiazine, 2,2-dioxide
CAS Number
1358751-06-0
Synonyms
  • NBI 1065845
Molecular Formula
C19H23N3O3S
Formula Weight
373.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S1(N=C2C(C3=CC=C(C=C3)OC4CCCCC4)=NC(C)=CN2CC1)=O
InChi Code
InChI=1S/C19H23N3O3S/c1-14-13-22-11-12-26(23,24)21-19(22)18(20-14)15-7-9-17(10-8-15)25-16-5-3-2-4-6-16/h7-10,13,16H,2-6,11-12H2,1H3
InChi Key
PXJBHEHFVQVDDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $127

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    10 mg

    $203

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    50 mg

    $633

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    100 mg

    $886

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    Product Description

    TAK-653 is an AMPA receptor positive allosteric modulator (PAM).1 It increases glutamate-induced calcium influx in CHO cells expressing human AMPA receptors (EC50 = 3.3 µM). TAK-653 potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons (EC50 = 4.4 µM). In vivo, TAK-653 (0.1-10 mg/kg) ameliorates MK-801-induced working memory deficits in the radial arm maze task in rats. It increases accuracy in the delayed match-to-sample (DMTS) test in cynomolgus monkeys when administered at a dose of 0.06 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, A., Kunugi, A., Tajima, Y., et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci. Rep. 11(1), 14532 (2021).