An internal standard for the quantification of carmustine
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Unlabeled Version(s)
15775Carmustine
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Carmustine-d8

Item No. 42213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-bis(2-chloroethyl-d8)-N-nitroso-urea
Synonyms
  • BCNU-d8
  • bis-Chloroethylnitrosourea-d8
Molecular Formula
C5HD8Cl2N3O2
Formula Weight
222.1
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleWater: soluble
SMILES
ClC([2H])([2H])C([2H])([2H])NC(N(N=O)C([2H])([2H])C([2H])([2H])Cl)=O
InChi Code
InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)/i1D2,2D2,3D2,4D2
InChi Key
DLGOEMSEDOSKAD-SVYQBANQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $160

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    5 mg

    $519

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    Product Description

    Carmustine-d8 is intended for use as an internal standard for the quantification of carmustine (Item No. 15775) by GC- or LC-MS. Carmustine is a DNA alkylating agent.1,2 It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM.2 In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the number of amyloid-β plaques and brain levels of amyloid-β (1-40) (Aβ40), as well as increases brain levels of soluble amyloid precursor protein (sAPP) in the APP/PS1 transgenic mouse model of Alzheimer’s disease.3 Formulations containing carmustine have been used in the treatment of gliomas and glioblastomas.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wasserman, T.H., Slavik, M., and Carter, S.K. Clinical comparison of the nitrosoureas. Cancer 36(4), 1258-1268 (1975).

    2. Soma, M.R., Baetta, R., De Renzis, M.R., et al. In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. Cancer Res. 55(3), 597-602 (1995).

    3. Hayes, C.D., Dey, D., Palavicini, J.P., et al. Striking reduction of amyloid plaque burden in an Alzheimer’s mouse model after chronic administration of carmustine. BMC Med. 11, 81 (2013).