An NSAID and COX-2 inhibitor
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Robenacoxib

Item No. 42218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]-benzeneacetic acid
CAS Number
220991-32-2
Synonyms
  • CGS 34975
Molecular Formula
C16H13F4NO2
Formula Weight
327.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CC1=CC(CC)=CC=C1NC2=C(F)C(F)=CC(F)=C2F)O
InChi Code
InChI=1S/C16H13F4NO2/c1-2-8-3-4-12(9(5-8)6-13(22)23)21-16-14(19)10(17)7-11(18)15(16)20/h3-5,7,21H,2,6H2,1H3,(H,22,23)
InChi Key
ZEXGDYFACFXQPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $46

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    25 mg

    $107

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    50 mg

    $204

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    100 mg

    $271

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    Product Description

    Robenacoxib is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (Ki = 30 nM for the human enzyme).1 It is selective for COX-2 over COX-1 (Ki = 800 nM for the ovine enzyme). Robenacoxib inhibits IL-1β-induced prostaglandin E2 (PGE2; Item No. 14010) production in human dermal fibroblasts (IC50 = 31 nM). It reduces carrageenan-induced paw edema (ID50 = 0.4 mg/kg), has antinociceptive activity in the Randall-Selitto test, and inhibits LPS-induced fever in rats. Formulations containing robenacoxib have been used in the treatment of post-operative pain and inflammation in cats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. King, J.N., Dawson, J., Esser, R.E., et al. Preclinical pharmacology of robenacoxib: A novel selective inhibitor of cyclooxygenase-2. J. Vet. Pharmacol. Ther. 32(1), 1-17 (2009).