A PDE5 inhibitor and an active metabolite of lodenafil carbonate
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Lodenafil

Item No. 42220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2-ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS Number
139755-85-4
Synonyms
  • Hydroxyhomosildenafil
Molecular Formula
C23H32N6O5S
Formula Weight
504.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CCOC1=C(C=C(S(=O)(N2CCN(CC2)CCO)=O)C=C1)C3=NC(C4=C(N3)C(CCC)=NN4C)=O
InChi Code
InChI=1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31)
InChi Key
NEYKRKVLEWKOBI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $160

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    25 mg

    $281

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    50 mg

    $422

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    Product Description

    Lodenafil is an inhibitor of phosphodiesterase 5 (PDE5) and an active metabolite of lodenafil carbonate.1,2 It enhances acetylcholine-induced relaxation of isolated human corpus cavernosum and rabbit cavernosal strips precontracted with phenylephrine (EC50s = 676 and 589 nM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alshehri, Y.M., Al-Majed, A.A., Attwa, M.W., et al. Lodenafil. Profiles of drug substances, excipients, and related methodology: Volume 47 113-147 (2022).

    2. Toque, H.A., Teixeira, C.E., Lorenzetti, R., et al. Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum. Eur. J. Pharmacol. 591(1-3), 189-195 (2008).