A chemo- and radioprotective agent
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UTL-5g

Item No. 42242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,4-dichlorophenyl)-5-methyl-3-isoxazolecarboxamide
CAS Number
646530-37-2
Molecular Formula
C11H8Cl2N2O2
Formula Weight
271.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=NOC(C)=C1)NC2=CC=C(Cl)C=C2Cl
InChi Code
InChI=1S/C11H8Cl2N2O2/c1-6-4-10(15-17-6)11(16)14-9-3-2-7(12)5-8(9)13/h2-5H,1H3,(H,14,16)
InChi Key
ULPKSWAQDCJLMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $238

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    50 mg

    $743

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    100 mg

    $1,040

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    Product Description

    UTL-5g is a chemo- and radioprotective agent.1,2,3 It reduces LPS-induced transcriptional activity mediated by a variety of immune-related transcription factors, including STAT1, STAT2, STAT3, and SMAD2-4 but not NF-κB in RAW 264.7 macrophages.2 It also reduces hyperphosphorylation of proteins involved in the G2/M phase transition, phagocytosis, and actin remodeling. It reduces radiation-induced increases in liver TNF-α levels in mice when administered at doses of 30 and 60 mg/kg and is protective against liver radiation-induced hepatotoxicity in mice at 60 mg/kg.1 Oral administration of UTL-5g (60 mg/kg) increases the survival rate in a mouse model of acute cisplatin (Item No. 13119) toxicity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shaw, J., Zhang, J., Zhang, M., et al. Pretreatment with a small-molecule tumor necrosis factor-alpha (TNF-α) inhibitor, UTL-5g, reduced radiation-induced acute liver toxicity in mice. Am. J. Biomed. Sci. 4(2), 123-131 (2011).

    2. Carruthers, N.J., Stemmer, P.M., Chen, B., et al. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur. J. Pharmacol. 811, 66-73 (2017).

    3. Shaw, J., Media, J., Chen, B., et al. The small-molecule TNF-α inhibitor, UTL-5g, delays deaths and increases survival rates for mice treated with high doses of cisplatin. Cancer Chemother. Pharmacol. 72(3), 703-707 (2013).