A 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist
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Quipazine (maleate)

Item No. 42262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1-piperazinyl)-quinoline, (2Z)-2-butenedioate (1:2)
CAS Number
150323-78-7
Molecular Formula
C13H15N3 • 2C4H4O4
Formula Weight
445.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCNCC2)=NC3=C(C=CC=C3)C=C1
InChi Code
InChI=1S/C13H15N3.2C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;2*5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChi Key
VAOSOCRJSSWBEQ-SPIKMXEPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $72

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    100 mg

    $137

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    250 mg

    $323

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    1 g

    $1,001

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    Product Description

    Quipazine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2B, and 5-HT2C.1 It induces calcium accumulation in CHO-K1 cells expressing 5-HT2A, 5-HT2B, or 5-HT2C (EC50s = 309.03, 177.83, and 338.84 nM, respectively, for the human receptors). Quipazine also binds to the 5-HT3 receptor (Ki = 2.1 nM).2 It decreases food intake in rats when administered at doses of 2.5, 5, or 10 mg/kg.3 Quipazine (0.3 mg/kg per day), in combination with 8-hydroxy DPAT (Item No. 22608), electrode stimulation of dorsal and lumbar spine regions, and locomotor training, restores spinal circuitry function, improves gait regularity, and increases interlimb coordination and limb weight-bearing in a rat model of hindlimb paralysis induced by spinal cord transection.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, R.H.P., Benwell, K.R., Lamb, H., et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br. J. Pharmacol. 128(1), 13-20 (1999).

    2. Schiavi, G.B., Brunet, S., Rizzi, C.A., et al. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33(3-4), 543-549 (1994).

    3. Samanin, R., Bendotti, C., Miranda, F., et al. Decrease of food intake by quipazine in the rat: Relation to serotoninergic receptor stimulation. J. Pharm. Pharmacol. 29(1), 53-54 (1977).

    4. Courtine, G., Gerasimenko, Y., van den Brand, R., et al. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat. Neurosci. 12(10), 1333-1342 (2009).