An oxysterol and active metabolite of cholesterol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

5β-Cholestan-3-one

Item No. 42284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
601-53-6
Synonyms
  • Coprostanone
  • NSC 119031
Molecular Formula
C27H46O
Formula Weight
386.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](CCCC(C)C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](CC(CC4)=O)([H])CC3)C
InChi Code
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-20,22-25H,6-17H2,1-5H3/t19-,20-,22+,23-,24+,25+,26+,27-/m1/s1
InChi Key
PESKGJQREUXSRR-JDIFZLMISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $87

    Add

    10 mg

    $165

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    5β-Cholestan-3-one is an oxysterol and active metabolite of cholesterol (Item Nos. 9003100 | 39088) produced by gut microbiota.1,2 It induces apoptosis in primary dog gallbladder epithelial cells when used at a concentration of 1.4 mM.1 Fecal levels of 5β-cholestan-3-one are increased in patients with colon cancer or adenomatous polyps.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seo, D.W., Choi, H.S., Lee, S.P., et al. Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture. Am. J. Physiol. Gastrointest. Liver Physiol. 287(6), G1247-G1256 (2004).

    2. Reddy, B.S., and Wynder, E.L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 39(6), 2533-2539 (1977).