An antiviral agent and a prodrug form of SB-9000
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SB-9200

Item No. 42317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-O-methyl-P(S)-[[[(1-methylethoxy)carbonyl]oxy]methyl]-P-thiouridylyl-(3'→5')-2'-deoxy-adenosine
CAS Number
942123-43-5
Synonyms
  • GS-9992
  • Inarigivir Soproxil
Molecular Formula
C25H34N7O13PS
Formula Weight
703.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mLEthanol: Sparingly soluble: 1-10 mg/mLPBS (pH 7.2): Sparingly soluble: 1-10 mg/mL
SMILES
O=P(O[C@@H]1[C@@H](CO)O[C@@H](N2C=CC(NC2=O)=O)[C@@H]1OC)(SCOC(OC(C)C)=O)OC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C54)C[C@@H]3O
InChi Code
InChI=1S/C25H34N7O13PS/c1-12(2)42-25(37)40-11-47-46(38,45-19-14(7-33)44-23(20(19)39-3)31-5-4-16(35)30-24(31)36)41-8-15-13(34)6-17(43-15)32-10-29-18-21(26)27-9-28-22(18)32/h4-5,9-10,12-15,17,19-20,23,33-34H,6-8,11H2,1-3H3,(H2,26,27,28)(H,30,35,36)/t13-,14+,15+,17+,19+,20+,23+,46?/m0/s1
InChi Key
CJCYTUJOSMYXLE-JDLSZIHUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $372

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    10 mg

    $620

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    25 mg

    $1,032

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    Cayman Chemical
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    Product Description

    SB-9200 is an antiviral agent and a prodrug form of SB-9000.1 It reduces replication of wild-type, lamivudine-resistant, or adefovir dipivoxil-resistant hepatitis B virus (HBV) in HepG2/2.15 cells (EC50s = 2.5, 2.1, and 2.8 µM, respectively). SB-9200 inhibits replication in genotype 1a or 1b hepatitis C virus (HCV) replicon cells (EC50s = 2.2 and 1 µM).2 It also decreases viability, migration and invasion, and the levels of STAT3 and phosphorylated STAT3 and increases the levels of DEAD-box helicase 58 (DDX58) in HCT116 and SW620 colon cancer cells when used at a concentration of 80 µM.3 SB-9200 (100 mg/kg) reduces hepatic levels of HBV DNA in HBV-infected mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coughlin, J.E., Padmanabhan, S., Zhang, G., et al. Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs. Bioorg. Med. Chem. Lett. 20(5), 1783-1786 (2010).

    2. Jones, M., Cunningham, M.E., Wing, P., et al. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. J. Med. Virol. 89(9), 1620-1628 (2017).

    3. Deng, Y., Fu, H., Han, X., et al. Activation of DDX58/RIG‑I suppresses the growth of tumor cells by inhibiting STAT3/CSE signaling in colon cancer. Int. J. Oncol. 61(4), 120 (2022).