A fluorogenic substrate for prolyl endopeptidase
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Cbz-Gly-Pro-AMC

Item No. 42320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-prolinamide
CAS Number
68542-93-8
Synonyms
  • Z-Gly-Pro-MeCouNH
Molecular Formula
C25H25N3O6
Formula Weight
463.5
Purity
≥98%
Emission
440-460 nm
Excitation
340-360 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C([C@H]1N(C(CNC(OCC2=CC=CC=C2)=O)=O)CCC1)NC3=CC(OC(C=C4C)=O)=C4C=C3
InChi Code
InChI=1S/C25H25N3O6/c1-16-12-23(30)34-21-13-18(9-10-19(16)21)27-24(31)20-8-5-11-28(20)22(29)14-26-25(32)33-15-17-6-3-2-4-7-17/h2-4,6-7,9-10,12-13,20H,5,8,11,14-15H2,1H3,(H,26,32)(H,27,31)/t20-/m0/s1
InChi Key
YWOXKKRKNGWXEG-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $106

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    10 mg

    $174

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    50 mg

    $675

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    Product Description

    Cbz-Gly-Pro-AMC is a fluorogenic substrate for prolyl endopeptidase.1 Upon enzymatic cleavage by prolyl endopeptidase, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify prolyl endopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshimoto, T., Ogita, K., Walter, R., et al. Post-proline cleaving enzyme. Synthesis of a new fluorogenic substrate and distribution of the endopeptidase in rat tissues and body fluids of man. Biochim. Biophys. Acta 569(2), 184-192 (1979).