A GAC inhibitor
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UPGL00004

Item No. 42323

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide
CAS Number
1890169-95-5
Synonyms
  • UP4
Molecular Formula
C25H26N8O2S2
Formula Weight
534.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(CC1=CC=CC=C1)NC(S2)=NN=C2NC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3
InChi Code
InChI=1S/C25H26N8O2S2/c34-20(15-17-7-3-1-4-8-17)27-23-30-29-22(36-23)26-19-11-13-33(14-12-19)25-32-31-24(37-25)28-21(35)16-18-9-5-2-6-10-18/h1-10,19H,11-16H2,(H,26,29)(H,27,30,34)(H,28,31,35)
InChi Key
MRYCNTHLPRENBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $139

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    25 mg

    $283

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    50 mg

    $479

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    Cayman Chemical
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    Product Description

    UPGL00004 is an inhibitor of glutaminase C (GAC; IC50 = 29 nM).1 It reduces the proliferation of MDA-MB-231, Hs 578T, and TSE breast cancer cells (IC50s = 70, 129, and 262 nM, respectively). UPGL00004 (0.1 µM) also inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus OC43 (HCoV-OC43) in Vero and primary human bronchial epithelial cells (HBECs), respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Q., Stalnecker, C., Zhang, C., et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. The Journal of Biological Chemisty 293(10), 3535-3545 (2018).

    2. Greene, K.S., Choi, A., Yang, N., et al. Glutamine metabolism is essential for coronavirus replication in host cells and in mice. The Journal of Biological Chemisty 301(1), 108063 (2025).