A molecular glue NF-κB degrader
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EN450

Item No. 42326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-chloro-5-[(dimethylamino)sulfonyl]phenyl]-2-propenamide
CAS Number
793719-01-4
Molecular Formula
C11H13ClN2O3S
Formula Weight
288.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)C=C
InChi Code
InChI=1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
InChi Key
OXFXDOLAQBMOPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $158

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    50 mg

    $578

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    100 mg

    $825

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    Cayman Chemical
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    Product Description

    EN450 is a molecular glue degrader of NF-κB.1 It covalently binds to ubiquitin-conjugating enzyme E2D (UBE2D) and induces ternary complex formation with NF-κB, which promotes NF-κB degradation. EN450 (50 µM) reduces the viability of HAP1 leukemia cells, an effect that can be reduced by MLN4924 (Item No. 15217) or bortezomib (Item No. 10008822).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. King, E.A., Cho, Y., Hsu, N.S., et al. Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB. Cell Chem. Biol. 30(4), 394-402 (2023).