A TEAD1 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

VT103

Item No. 42327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-benzenesulfonamide
CAS Number
2290608-13-6
Molecular Formula
C18H17F3N4O2S
Formula Weight
410.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mL
SMILES
O=S(NC)(C1=CC(C2=CN(C)C=N2)=C(NC3=CC=C(C(F)(F)F)C=C3)C=C1)=O
InChi Code
InChI=1S/C18H17F3N4O2S/c1-22-28(26,27)14-7-8-16(15(9-14)17-10-25(2)11-23-17)24-13-5-3-12(4-6-13)18(19,20)21/h3-11,22,24H,1-2H3
InChi Key
LLCVDQHLYHBAHR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $83

    Add

    5 mg

    $330

    Add

    10 mg

    $620

    Add

    25 mg

    $1,032

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    VT103 is an inhibitor of TEA domain transcription factor 1 (TEAD1; IC50 = 1.02 nM).1 It inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2, TEAD3, or TEAD4 when used at a concentration of 3 µM. VT103 also inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 pleural mesothelioma cells. In vivo, VT103 (0.3-10 mg/kg) reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tang, T.T., Konradi, A.W., Feng, Y., et al. Small molecule inhibitors of TEAD auto-palmitoylation selectively inhibit proliferation and tumor growth of NF2-deficient mesothelioma. Mol. Cancer Ther. 20(6), 986-998 (2021).