A TEAD1 inhibitor
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VT103

Item No. 42327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-benzenesulfonamide
CAS Number
2290608-13-6
Molecular Formula
C18H17F3N4O2S
Formula Weight
410.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mL
SMILES
O=S(NC)(C1=CC(C2=CN(C)C=N2)=C(NC3=CC=C(C(F)(F)F)C=C3)C=C1)=O
InChi Code
InChI=1S/C18H17F3N4O2S/c1-22-28(26,27)14-7-8-16(15(9-14)17-10-25(2)11-23-17)24-13-5-3-12(4-6-13)18(19,20)21/h3-11,22,24H,1-2H3
InChi Key
LLCVDQHLYHBAHR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $330

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    10 mg

    $620

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    25 mg

    $1,032

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    Product Description

    VT103 is an inhibitor of TEA domain transcription factor 1 (TEAD1; IC50 = 1.02 nM).1 It inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2, TEAD3, or TEAD4 when used at a concentration of 3 µM. VT103 also inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 pleural mesothelioma cells. In vivo, VT103 (0.3-10 mg/kg) reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tang, T.T., Konradi, A.W., Feng, Y., et al. Small molecule inhibitors of TEAD auto-palmitoylation selectively inhibit proliferation and tumor growth of NF2-deficient mesothelioma. Mol. Cancer Ther. 20(6), 986-998 (2021).