A prodrug form of N-glutaryl-L-alanine and a GGCT inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Cancer

Pro-GA

Item No. 42353

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[(1S)-2-[(acetyloxy)methoxy]-1-methyl-2-oxoethyl]amino]-5-oxo-pentanoic acid, methyl ester
CAS Number
2222067-12-9
Synonyms
  • Pro-glutaryl Alanine
Molecular Formula
C12H19NO7
Formula Weight
289.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
COC(CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O)=O
InChi Code
InChI=1S/C12H19NO7/c1-8(12(17)20-7-19-9(2)14)13-10(15)5-4-6-11(16)18-3/h8H,4-7H2,1-3H3,(H,13,15)/t8-/m0/s1
InChi Key
GYBSTWDRGMHMOZ-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    2 mg

    $659

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Pro-GA is a prodrug form of N-glutaryl-L-alanine and an inhibitor of γ-glutamylcyclotransferase (GGCT), an enzyme involved in glutathione metabolism.1 It reduces the viability of RT-112 bladder cancer cells, which have a high expression of GGCT (IC50 = 73.9 µM), and UM-UC-3 and T24 bladder cancer cells (IC50s = 58.5 and 57 µM, respectively). It enhances growth inhibition induced by mitomycin C (Item No. 11435) in RT-112 cells. Pro-GA (50, 75, and 100 µM) also inhibits the proliferation of MCF-7 breast cancer cells.2 It increases the production of reactive oxygen species (ROS) and induces senescence in MCF-7 cells, effects that can be blocked by N-acetylcysteine (NAC). Pro-GA (25 mg/kg) reduces tumor weight in an MCF-7 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hanada, E., Kageyama, S., Murai, R., et al. Pro-GA, a novel inhibitor of γ-glutamylcyclotransferase, suppresses human bladder cancer cell growth. Anticancer Res. 39(4), 1893-1898 (2019).

    2. Ii, H., Taniguchi, K., Yoshiya, T., et al. The γ-glutamylcyclotransferase inhibitor Pro-GA induces an antiproliferative effect through the generation of mitochondrial reactive oxygen species. Anticancer Res. 42(9), 4311-4317 (2022).