A quenched fluorescent probe for GSTP1 activity
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Ps-Tac

Item No. 42357

Product Insert (PDF)
Technical Information
Purity
≥95%
Emission
510 nm
Excitation
493 nm
Formulation (Request formulation change)
A solid
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea

    $578

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    Product Description

    Ps-Tac is a cell-permeable quenched fluorescent probe for the detection of glutathione S-transferase π 1 (GSTP1) activity in live cells. It is selective for GSTP1 over 18 GST subtypes in MCF-7 cells expressing the recombinant human enzymes. Ps-Tac is composed of a fluorescein derivative protected by the GSTP1 substrate 5-mesyl-2-nitrobenzanilide.1 Upon glutathionylation by GSTP1, nitrite is released, and the fluorescence of the unquenched glutathionylated fluorescein derivative can be quantified using excitation/emission maxima of 493/510 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mori, M., Fujikawa, Y., Kikkawa, M., et al. A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development and cellular applicability in epigenetic studies. Chem. Commun. (Camb) 55(56), 8122-8125 (2019).