A bacterial metabolite with antimicrobial and anticancer activities
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Lavendamycin

Item No. 42360

Product Insert (PDF)
Technical Information
Formal Name
1-(7-amino-5,8-dihydro-5,8-dioxo-2-quinolinyl)-4-methyl-9H-pyrido[3,4-b]indole-3-carboxylic acid
CAS Number
81645-09-2
Synonyms
  • NSC 322370
Molecular Formula
C22H14N4O4
Formula Weight
398.4
Purity
≥90%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=NC(C(N=C2C(C(N)=C3)=O)=CC=C2C3=O)=C4NC5=C(C4=C1C)C=CC=C5)O
InChi Code
InChI=1S/C22H14N4O4/c1-9-16-10-4-2-3-5-13(10)24-20(16)19(26-17(9)22(29)30)14-7-6-11-15(27)8-12(23)21(28)18(11)25-14/h2-8,24H,23H2,1H3,(H,29,30)
InChi Key
IGQJRDIREIWBQP-UHFFFAOYSA-N
Origin
Bacterium/Actinoplanes sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $692

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    Product Description

    Lavendamycin is a bacterial metabolite that has been found in S. lavendulae and has antimicrobial and anticancer activities.1,2 It is active against various bacteria, including S. pneumoniae, S. aureus, E. coli, P. mirabilis, and P. vulgaris (MICs = 0.13-1 µg/ml), and various fungi, including T. rubrum, T. mentagrophytes, and M. canis (MICs = 0.5 µg/ml for all).1 Lavendamycin is cytotoxic to P388 murine leukemia, MKN45 gastric carcinoma, and WiDr colon adenocarcinoma cells (IC50s = 0.06, 0.1, 0.09 µg/ml, respectively).2 In vivo, lavendamycin (0.4-6.4 mg/kg) increases median survival time in a P388 murine leukemia model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balitz, D.M., Bush, J.A., Bradner, W.T., et al. Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulae. J. Antibiot. (Tokyo) 35(3), 259-265 (1982).

    2. Abe, N., Nakakita, Y., Nakamura, T., et al. Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. I. Taxonomy of the producing organism, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 46(11), 1672-1677 (1993).