Dauricine

Dauricine is an isoquinoline alkaloid that has been found in M. dauricum and has diverse biological activities.^1,2,3 It inhibits IL-1β-induced THP-1 monocyte adhesion to human umbilical vein endothelial cells (HUVECs) when used at concentrations of 20 or 40 µM.¹ Dauricine (40 µM) inhibits IL-1β-induced increases in intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin levels and activation of NF-κB in HUVECs. It inhibits slowly activating delayed rectifier- (IK_s) and rapidly activating delayed rectifier potassium currents (IK_r) in whole-cell patch-clamp assays using isolated guinea pig ventricular myocytes (IC₅₀s = 16 and 33 µM, respectively).² Dauricine (20 µM) inhibits inward rectifying potassium channel (K_ir) currents in the same cells. It also inhibits copper-induced paralysis and decreases in survival in C. elegans when used at a concentration of 6.4 µM.³ Dauricine (20 mg/kg) increases survival in a mouse model of LPS-induced acute lung injury.¹

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1. Hu, J., Chen, R., An, J., et al. Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway. Front. Pharmacol. 12, 758962 (2021).

2. Xia, J.-S., Guo, D.-L., Zhang, Y., et al. Inhibitory effects of dauricine on potassium currents in guinea pig ventricular myocytes. Acta. Pharmacol. Sin. 21(1), 60-64 (2000).

3. Wang, L., Pu, Z., Li, M., et al. Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer’s disease models. Life Sci. 243, 117237 (2020).