A CYP26 inhibitor
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Talarozole

Item No. 42372

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine
CAS Number
201410-53-9
Synonyms
  • R115866
  • Rambazole
Molecular Formula
C21H23N5S
Formula Weight
377.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mLEthanol: Sparingly Soluble: 1-10 mg/mL
SMILES
CCC(CC)C(C1=CC=C(NC2=NC3=CC=CC=C3S2)C=C1)N4N=CN=C4
InChi Code
InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
InChi Key
SNFYYXUGUBUECJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $179

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    25 mg

    $314

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    50 mg

    $418

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    Product Description

    Talarozole is an inhibitor of cytochrome P450 (CYP) isoform 26 (CYP26; IC50 = 0.004 µM).1 It is selective for CYP26 over CYP2A1, CYP2C11, CYP17, and CYP19 (IC50s = 9.1, 7.2, 2.6, and 1.3 µM, respectively). Talarozole (2.5 mg/kg) increases the levels of all-trans retinoic acid in plasma, skin, liver, fat, kidneys, and spleen in rats. It inhibits estrogen-induced vaginal keratinization in ovariectomized rats (ED50 = 1 mg/kg), an effect that can be reversed by AGN 193109 (Item No. 23975). Talarozole (0.6-2.6 mg/kg) increases pinnal epidermal thickness and tail epidermal orthokeratosis percentage in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stoppie, P., Borgers, M., Borghgraef, P., et al. R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents. J. Pharmacol. Exp. Ther. 293(1), 304-312 (2000).