A G protein-biased agonist of GPR84
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OX04528

Item No. 42377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-[3,5-bis(trifluoromethyl)phenyl]propyl]-3-pyridinol, 1-oxide
CAS Number
3028055-45-7
Molecular Formula
C16H13F6NO2
Formula Weight
365.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mLEthanol: Slightly Soluble: 0.1-1 mg/mL
SMILES
OC1=CC(CCCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=C[N](=O)=C1
InChi Code
InChI=1S/C16H13F6NO2/c17-15(18,19)12-4-10(5-13(7-12)16(20,21)22)2-1-3-11-6-14(24)9-23(25)8-11/h4-9,24H,1-3H2
InChi Key
DPLHUGXFERHOJE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $86

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    10 mg

    $154

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    25 mg

    $323

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    50 mg

    $558

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    Product Description

    OX04528 is a G protein-biased agonist of G protein-coupled receptor 84 (GPR84).1 It inhibits forskolin-induced cAMP production in CHO cells expressing human GPR84 (EC50 = 0.00598 nM) and does not induce ß-arrestin recruitment when used at concentrations up to 80 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, P., Raja, A., Luscombe, V.B., et al. Development of highly potent, G-protein pathway biased, selective, and orally bioavailable GPR84 agonists. J. Med. Chem. 67(1), 110-137 (2024).