An inhibitor of AChE and BChE and a fluorescent probe for Aβ
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PE154

Item No. 42396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[7-(diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid, 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
CAS Number
1192750-33-6
Molecular Formula
C35H35N5O4
Formula Weight
589.7
Purity
≥98%
Emission
517 nm
Excitation
405 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1OC2=CC(N(CC)CC)=CC=C2C(C1=CNC3=CC=C(CC(NNC4=C(CCCC5)C5=NC6=C4C=CC=C6)=O)C=C3)=O
InChi Code
InChI=1S/C35H35N5O4/c1-3-40(4-2)24-17-18-27-31(20-24)44-35(43)28(34(27)42)21-36-23-15-13-22(14-16-23)19-32(41)38-39-33-25-9-5-7-11-29(25)37-30-12-8-6-10-26(30)33/h5,7,9,11,13-18,20-21,36H,3-4,6,8,10,12,19H2,1-2H3,(H,37,39)(H,38,41)
InChi Key
CYZIIGRHLSZNAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $39

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    5 mg

    $174

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    10 mg

    $270

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    25 mg

    $482

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    Product Description

    PE154 is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.28 and 16 nM, respectively).1 It is also a fluorescent probe for amyloid-ß (Aß) plaques that displays excitation and emission maxima of 405 and 517 nm, respectively. PE154 selectively binds to Aß over phosphorylated tau in a 3xTg mouse model of Alzheimer’s disease when delivered via intrahippocampal administration of nanoparticles containing PE154.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elsinghorst, P.W., Härtig, W., Goldhammer, S., et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org. Biomol. Chem. 7(19), 3940-3946 (2009).

    2. Härtig, W., Kacza, J., Paulke, B.R., et al. In vivo labelling of hippocampal β-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur. J. Neurosci. 31(1), 99-109 (2010).