A TG2 inhibitor
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BJJF078

Item No. 42397

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dimethoxy-N-[5-[[4-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]sulfonyl]-1-naphthalenyl]-benzamide
CAS Number
2531244-56-9
Molecular Formula
C27H29N3O6S
Formula Weight
523.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(C(OC)=C1)OC)NC2=CC=CC3=C(S(=O)(N4CCC(NC(C=C)=O)CC4)=O)C=CC=C32
InChi Code
InChI=1S/C27H29N3O6S/c1-4-26(31)28-19-13-15-30(16-14-19)37(33,34)25-10-6-7-20-21(25)8-5-9-22(20)29-27(32)18-11-12-23(35-2)24(17-18)36-3/h4-12,17,19H,1,13-16H2,2-3H3,(H,28,31)(H,29,32)
InChi Key
IJRQXDUGUAWTNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $90

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    10 mg

    $152

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    25 mg

    $241

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    Product Description

    BJJF078 is an inhibitor of transglutaminase 2 (TG2; IC50s = 41 and 54 nM for the human and mouse enzymes, respectively).1 It is selective for TG2 over Factor XII (IC50 = 22 µM for the human enzyme) but does inhibit TG1 (IC50 = 0.16 µM for the human enzyme).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chrobok, N.L., Bol, J.G.J.M., Jongenelen , C.A., et al. Characterization of transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis. PLoS One 13(4), e0196433 (2018).