A state-dependent sodium channel inhibitor
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Co 102862

Item No. 42437

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(4-fluorophenoxy)phenyl]methylene]-hydrazinecarboxamide
CAS Number
181144-66-1
Synonyms
  • V 102862
Molecular Formula
C14H12FN3O2
Formula Weight
273.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(NN=CC1=CC=C(C=C1)OC2=CC=C(C=C2)F)N
InChi Code
InChI=1S/C14H12FN3O2/c15-11-3-7-13(8-4-11)20-12-5-1-10(2-6-12)9-17-18-14(16)19/h1-9H,(H3,16,18,19)
InChi Key
MHUUDVZSPFRUSK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $47

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    10 mg

    $88

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    50 mg

    $278

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    100 mg

    $462

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    Product Description

    Co 102862 is a state-dependent inhibitor of voltage-gated sodium channels (Nav).1 It selectively binds to inactivated Nav channels over resting Nav channels (Kis = 0.6 and >15 µM, respectively). Co 102862 (1 µM) inhibits sodium currents (INa) in primary rat acutely dissociated hippocampal neurons. In vivo, Co 102862 inhibits early- and late-phase nociceptive responses in the formalin test in mice (ED50s = 10.6 and 5.2 mg/kg, respectively).2 It also reduces the number of tonic seizures induced by maximum electroshock (MES) in mice and rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ilyin, V.I., Hodges, D.D., Whittemore, E.R., et al. V102862 (Co 102862): A potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br. J. Pharmacol. 144(6), 801-812 (2005).

    2. Ramu, K., Lam, G.N., and Hughes, H. In vivo metabolism and mass balance of 4-[4-fluorophenoxy]benzaldehyde semicarbazone in rats. Drug Metab. Dispos. 28(10), 1153-1161 (2000).