An activator of KATP channels
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ZM 226600

Item No. 42440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3,3-trifluoro-2-hydroxy-2-methyl-N-[4-(phenylsulfonyl)phenyl]-propanamide
CAS Number
147695-92-9
Molecular Formula
C16H14F3NO4S
Formula Weight
373.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(C(O)(C(NC(C=C1)=CC=C1S(C2=CC=CC=C2)(=O)=O)=O)C)F
InChi Code
InChI=1S/C16H14F3NO4S/c1-15(22,16(17,18)19)14(21)20-11-7-9-13(10-8-11)25(23,24)12-5-3-2-4-6-12/h2-10,22H,1H3,(H,20,21)
InChi Key
LJLXQHHFAKVTNP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $75

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    10 mg

    $105

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    50 mg

    $374

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    100 mg

    $674

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    Product Description

    ZM 226600 is an activator of ATP-sensitive potassium channels (KATP).1 It induces relaxation of potassium-precontracted isolated guinea pig bladder detrusor muscle strips (EC50 = 0.5 µM). ZM 226600 reduces bladder overactivity in a rat model of ligature-intact partial urethral obstruction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grant, T.L., Ohnmacht, C.J., and Howe, B.B. Anilide tertiary carbinols: A novel series of K+ channel openers. Trends Pharmacol. Sci. 15(11), 402-414 (1994).

    2. Pinna, C., Sanvito, P., Bolego, C., et al. Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur. J. Pharmacol. 516(1), 71-77 (2005).