A DUSP22 inhibitor
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BML-260

Item No. 42442

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-oxo-5-(phenylmethylene)-2-thioxo-3-thiazolidinyl]-benzoic acid
CAS Number
101439-76-3
Molecular Formula
C17H11NO3S2
Formula Weight
341.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(C(S1)=CC2=CC=CC=C2)N(C3=CC=C(C(O)=O)C=C3)C1=S
InChi Code
InChI=1S/C17H11NO3S2/c19-15-14(10-11-4-2-1-3-5-11)23-17(22)18(15)13-8-6-12(7-9-13)16(20)21/h1-10H,(H,20,21)
InChi Key
HJGHAHOKZBWVGK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    50 mg

    $432

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    100 mg

    $755

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    Product Description

    BML-260 is an inhibitor of dual-specificity phosphatase 22 (DUSP22).1 In vivo, BML-260 (1 mg/kg) increases expression of Ucp1, the gene encoding the thermogenic protein uncoupling protein 1 (Ucp1), in white adipocytes and induces thermogenesis in mice.1 Xenotransplantation of BML-260-expanded hematopoietic stem cells (HSCs) increases immune cell content in immunocompromised mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, Z., Wei, Y., Zhang, Y., et al. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression. Theranostics 9(12), 3501-3514 (2019).

    2. Albayrak, E., Akgol, S., Turan, R.D., et al. BML-260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability. J. Cell Biochem. 123(12), 2009-2029 (2022).