A PRMT9 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LD2

Item No. 42447

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole
CAS Number
1134334-55-6
Molecular Formula
C12H10ClN3O
Formula Weight
247.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥ 10 mg/mlDMSO: Sparingly soluble: 1/10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=NC=NC2=C1N(C)C3=C2C=C(C=C3)OC
InChi Code
InChI=1S/C12H10ClN3O/c1-16-9-4-3-7(17-2)5-8(9)10-11(16)12(13)15-6-14-10/h3-6H,1-2H3
InChi Key
VKWOHOPWHUHGQV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    10 mg

    $142

    Add

    25 mg

    $337

    Add

    50 mg

    $636

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    LD2 is an inhibitor of protein arginine methyltransferase 9 (PRMT9; IC50 = 0.9 µM).1 It reduces the proliferation of Rec-1 and Raji lymphoblasts, UPN1 mantle cell lymphoma, BL-41 Burkitt lymphoma, and OCI-Ly3 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.5-5 µM). LD2 (2.5 µM) induces cell cycle arrest at the G2/M phase in THP-1 acute myeloid leukemia (AML) cells. It decreases phosphorylated levels of checkpoint kinase 1 (Chk1) and Chk2 in THP-1 cells. In vivo, LD2 (10 mg/kg twice per day), in combination with an anti-programmed cell death protein 1 (anti-PD-1) antibody, decreases tumor volume in an AML mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, L., Dong, H., Zhang, L., et al. Protein arginine methyltransferase 9 inhibitors and methods of use. AS 2024/0132887 Al, (2024).