An agonist of LXRα and LXRβ
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IMB-808

Item No. 42448

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-1,4-benzodioxin-6-carboxamide
CAS Number
870768-70-0
Molecular Formula
C18H15F3N2O4
Formula Weight
380.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N(CC(NC1=CC=C(F)C(F)=C1F)=O)C)C2=CC=C3OCCOC3=C2
InChi Code
InChI=1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24)
InChi Key
XITZPIXICJOKTF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    IMB-808 is an agonist of liver X receptor α (LXRα) and LXRβ.1 It induces transactivation of LXRα and LXRβ in reporter assays using HEK293T cells (EC50s = 0.15 and 0.53 µM, respectively). IMB-808 (1 and 10 µM) increases protein levels of ATP-binding cassette transporter 1, subfamily G (ABCG1) and ATP-binding cassette transporter 1, subfamily A (ABCA1) in RAW 264.7 and THP-1 cells. It induces cholesterol efflux and reduces oxidized LDL-induced lipid accumulation in RAW 264.7 cells when used at concentrations of 1 or 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, N., Wang, X., Xu, Y., et al. Identification of a novel liver X receptor agonist that regulates the expression of key cholesterol homeostasis genes with distinct pharmacological characteristics. Mol. Pharmacol. 91(4), 264-276 (2017).