A GAT1 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SKF 89976A (hydrochloride)

Item No. 42449

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4,4-diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid, monohydrochloride
CAS Number
85375-15-1
Molecular Formula
C22H25NO2 • HCl
Formula Weight
371.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml”Ethanol: Sparingly Soluble: 1-10 mg/ml”PBS pH 7.2: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(C1CN(CCC1)CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)O.Cl
InChi Code
InChI=1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
InChi Key
SNGGBKYQZVAQKA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $44

    Add

    10 mg

    $84

    Add

    25 mg

    $198

    Add

    50 mg

    $374

    Add
    Product Description

    SKF 89976A is an inhibitor of GABA transporter 1 (GAT1; IC50s = 0.13 and 0.64 µM for the human and rat transporters, respectively).1 It is selective for GAT1 over rat GAT2, human GAT3, and human betaine/GABA transporter 3 (BGT3; IC50s = 550, 944, and 7,210 µM, respectively). SKF 89976A inhibits GABA uptake in rat synaptosome preparations (IC50 = 341 nM).2 It inhibits DMCM-induced seizures in mice (ED50 = 3.1 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Borden, L.A., Murali Dhar, T.G., Smith, K.E., et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur. J. Pharmacol. 269(2), 219-224 (1994).

    2. Andersen, K.E., Braestrup, C., Grønwald, F.C., et al. The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate. J. Med. Chem. 36(12), 1716-1725 (1993).